Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 2/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698062 | 0.82 | KHK (0.39) | MEN1KMT2AALDH1A1P2RX7PDE10A | |
| SCHEMBL24699355 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1IGF1R | |
| SCHEMBL29134848 | 0.80 | IGF1R (0.34) | MEN1KMT2AKDM4EALDH1A1IGF1R | |
| SCHEMBL30017019 | 0.80 | MTOR (0.38) | KDM4E | |
| SCHEMBL24698052 | 0.80 | IGF1R (0.34) | MEN1KMT2AKDM4EALDH1A1IGF1R | |
| SCHEMBL24698053 | 0.80 | PIK3CD (0.38) | BMPR1AACVRL1ACVR1P2RX7KHK | |
| SCHEMBL24698700 | 0.80 | MTOR (0.38) | KDM4E | |
| SCHEMBL24699489 | 0.79 | GSK3B (0.35) | ALDH1A1 | |
| SCHEMBL24698803 | 0.79 | KDM4E (0.34) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL24699075 | 0.79 | KCNH2 (0.36) | MEN1KMT2AALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |