Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 8/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD1 | O95696 | 2/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30014813 | 1.00 | MAPK1 (0.34) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699069 | 0.93 | PI4KB (0.35) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30015941 | 0.93 | PI4KB (0.35) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30016531 | 0.89 | PI4KB (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24697976 | 0.89 | PI4KB (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699210 | 0.87 | MTOR (0.35) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30015825 | 0.87 | MTOR (0.35) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699229 | 0.84 | MTOR (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30016058 | 0.84 | MTOR (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699239 | 0.82 | HMOX1 (0.34) | MTORBRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |