Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.33 |
| ▸ | FECH | P22830 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.33 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.33 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699239 | 0.89 | HMOX1 (0.34) | MTOR | |
| SCHEMBL24697981 | 0.85 | PIK3R1 (0.36) | MTORPIK3CAPIK3R1KCNH2 | |
| SCHEMBL24699603 | 0.83 | BRD4 (0.37) | PIK3CAPIK3R1 | |
| SCHEMBL30015790 | 0.80 | MTOR (0.32) | MTOR | |
| SCHEMBL24698640 | 0.80 | MTOR (0.32) | MTOR | |
| SCHEMBL30016531 | 0.78 | PI4KB (0.36) | MTOR | |
| SCHEMBL24697976 | 0.78 | PI4KB (0.36) | MTOR | |
| SCHEMBL24699229 | 0.77 | MTOR (0.36) | MTORKCNH2 | |
| SCHEMBL30016058 | 0.77 | MTOR (0.36) | MTORKCNH2 | |
| SCHEMBL24699069 | 0.76 | PI4KB (0.35) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |