Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 7/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699352 | 0.82 | BMPR1A (0.35) | KDM4EALDH1A1IGF1R | |
| SCHEMBL24698063 | 0.79 | GBA1 (0.37) | KDM4EALDH1A1IGF1RGBA1SMN1; SMN2 | |
| SCHEMBL24698054 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698050 | 0.76 | IGF1R (0.41) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698701 | 0.76 | TDP1 (0.41) | KDM4EALDH1A1GBA1SMN1; SMN2HSD17B10 | |
| SCHEMBL24699477 | 0.75 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL27013447 | 0.75 | KMT2A (0.47) | — | |
| SCHEMBL24699490 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698638 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698171 | 0.74 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDGBA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |