Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015914 | 1.00 | MAPK1 (0.41) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699229 | 0.86 | MTOR (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30016058 | 0.86 | MTOR (0.36) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL30016865 | 0.86 | AR (0.36) | KDM4EHPGDARALDH1A1GAA | |
| SCHEMBL24698160 | 0.86 | AR (0.36) | KDM4EHPGDARALDH1A1GAA | |
| SCHEMBL30016357 | 0.86 | MTOR (0.44) | MTORKDM1A | |
| SCHEMBL24699037 | 0.86 | MTOR (0.44) | MTORKDM1A | |
| SCHEMBL24699497 | 0.85 | HSD17B10 (0.43) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699243 | 0.85 | KDM1A (0.33) | MAPK1HSD17B10USP2KDM4EHPGD | |
| SCHEMBL24699484 | 0.82 | PDE7A (0.41) | MAPK1HSD17B10USP2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |