Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.41 |
| ▸ | POLRMT | O00411 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 6/20 | 0.40 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.38 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20059049 | 0.87 | POLRMT (0.55) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL20404123 | 0.82 | FUT5 (0.41) | P2RX3P2RX1P2RX4P2RY1P2RY2 | |
| SCHEMBL24700209 | 0.81 | POLRMT (0.48) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL24791257 | 0.78 | NPC1 (0.40) | SRCSMN1; SMN2 | |
| SCHEMBL23960110 | 0.77 | POLRMT (0.57) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL15682898 | 0.77 | P2RX1 (0.46) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL12254003 | 0.76 | P2RY2 (0.45) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL9912288 | 0.76 | POLB (0.33) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL881477 | 0.76 | P2RX1 (0.44) | P2RX3P2RX1P2RX2POLRMTP2RX4 | |
| SCHEMBL22107764 | 0.75 | POLRMT (0.39) | P2RX3P2RX1P2RX2POLRMTP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909209-B1 | 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME LLC (US) | 2022-08-03 | — | — | EP | disclosed |