Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 7/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512692 | 1.00 | TP53 (0.48) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512690 | 1.00 | TP53 (0.48) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512783 | 0.94 | MLNR (0.47) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512873 | 0.94 | MLNR (0.47) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512730 | 0.90 | TP53 (0.46) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512793 | 0.89 | RORC (0.49) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512467 | 0.89 | TP53 (0.45) | TP53HIF1AEPAS1PRKAB2PRKAG1 | |
| SCHEMBL1512302 | 0.86 | PRKAB2 (0.60) | HIF1AEPAS1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2471116 | 0.83 | PRKAB2 (0.56) | HIF1AEPAS1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1870876 | 0.81 | TP53 (0.49) | TP53HIF1AEPAS1USP30MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102026986-B | Hexafluoroisopropanol derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-10-29 | — | — | CN | disclosed |
| US-8357679-B2 | Hexafluoroisopropanol derivatives | MSD OSS B.V. (NL) | 2013-01-22 | — | — | US | disclosed |
| US-8357679-B2 | Hexafluoroisopropanol derivatives | MSD OSS B.V. (NL) | 2013-01-22 | — | — | US | disclosed |
| US-8357679-B2 | Hexafluoroisopropanol derivatives | MSD OSS B.V. (NL) | 2013-01-22 | — | — | US | disclosed |
| EP-2297118-B1 | N- (1, 1, 1, 3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) BENZYL-N' -ARYLCARBONYLPIPERAZ INE DERIVATIVES AS LXR MODULATORS | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| US-20100029621-A1 | HEXAFLUOROISOPROPANOL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2010-02-04 | — | — | US | disclosed |
| US-20100029621-A1 | HEXAFLUOROISOPROPANOL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2010-02-04 | — | — | US | disclosed |
| US-20100029621-A1 | HEXAFLUOROISOPROPANOL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2010-02-04 | — | — | US | disclosed |
| WO-2009138438-A1 | N- (1, 1, 1, 3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) BENZYL-N' -ARYLCARBONYLPIPERAZ INE DERIVATIVES | N.V. ORGANON (NL) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029621-A1 | HEXAFLUOROISOPROPANOL DERIVATIVES | FFAR2, FFAR3, FFAR1 | TP53 4049/4885HIF1A 500/4885EPAS1 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.