Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31141403 | 0.98 | ALDH1A1 (0.44) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL24709610 | 0.84 | ALDH1A1 (0.46) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| Bromide SCHEMBL31141392 | 0.82 | ALDH1A1 (0.45) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL24709607 | 0.82 | ALDH1A1 (0.67) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL24709613 | 0.82 | SMN1; SMN2 (0.57) | ALDH1A1POLBSMN1; SMN2LMNARAB9A | |
| SCHEMBL246385 | 0.81 | SIGMAR1 (0.48) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| Bromide SCHEMBL31141416 | 0.81 | SMN1; SMN2 (0.55) | ALDH1A1POLBSMN1; SMN2LMNARAB9A | |
| Bromide SCHEMBL31141385 | 0.81 | ALDH1A1 (0.65) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL20569065 | 0.80 | HPGD (0.45) | ALDH1A1POLBKDM4ESMN1; SMN2CYP11B1 | |
| SCHEMBL11809969 | 0.80 | POLB (0.69) | ALDH1A1POLBKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022257581-A1 | A CLASS OF IMIDAZOLIDINOPYRIMIDONE COMPOUNDS AND USE THEREOF IN TREATMENT OF HSCLPP-MEDIATED DISEASES | 四川大学 | 2022-12-15 | — | — | WO | disclosed |