Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246385 | 0.83 | SIGMAR1 (0.48) | CYP2D6ALDH1A1POLBCYP3A4CYP2C19 | |
| Bromide SCHEMBL11669278 | 0.81 | SIGMAR1 (0.47) | CYP2D6ALDH1A1POLBCYP3A4CYP2C19 | |
| SCHEMBL24709610 | 0.81 | ALDH1A1 (0.46) | ALDH1A1POLBCYP2C19CYP11B1CYP2C9 | |
| SCHEMBL24709607 | 0.80 | ALDH1A1 (0.67) | CYP2D6ALDH1A1POLBCYP3A4CYP2C19 | |
| SCHEMBL24709613 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1POLBCYP11B1SMN1; SMN2 | |
| SCHEMBL24709604 | 0.80 | ALDH1A1 (0.45) | ALDH1A1POLBCYP2C19CYP11B1CYP2C9 | |
| Bromide SCHEMBL31141392 | 0.80 | ALDH1A1 (0.45) | ALDH1A1POLBCYP2C19CYP11B1CYP2C9 | |
| SCHEMBL7999499 | 0.80 | CHRNB2 (0.54) | ALDH1A1CYP11B1TDP1KDM4ESMN1; SMN2 | |
| SCHEMBL24709611 | 0.80 | ALDH1A1 (0.50) | ALDH1A1POLBCYP3A4L3MBTL1KDM4E | |
| SCHEMBL9677155 | 0.79 | POLB (0.66) | HPGDCYP2D6ALDH1A1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200179361-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | TORREY PINES INST FOR MOLECULAR STUDIES (US) | 2020-06-11 | — | — | US | disclosed |
| WO-2018217631-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200179361-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | CHRNA4, CHRNA5, CHRNB4 | HPGD 1684/4885CYP2D6 2997/4885ALDH1A1 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.