SCHEMBL24710

SCHEMBL24710

COCOC1CCc2cc(C=O)ccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.35
TSHR P16473 1/20 0.35
HPGD P15428 2/20 0.35
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
FDPS P14324 1/20 0.34
TDP1 Q9NUW8 2/20 0.33
AOX1 Q06278 1/20 0.33
TRIM24 O15164 1/20 0.33
ALDH5A1 P51649 1/20 0.33
ABAT P80404 1/20 0.33
TRIM33 Q9UPN9 1/20 0.33
PPARD Q03181 2/20 0.32
ALDH1A3 P47895 1/20 0.31
CYP2A6 P11509 1/20 0.31
MAOB P27338 1/20 0.31
PTGER4 P35408 1/20 0.31
ESR1 P03372 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24616 0.84 ALDH1A1 (0.40) ALDH1A1TSHRHPGDMEN1GAA
SCHEMBL24859 0.83 ALDH1A1 (0.33) ALDH1A1MEN1GAAMAPTKMT2A
SCHEMBL24860 0.83 ALDH1A1 (0.33) ALDH1A1MEN1GAAMAPTKMT2A
SCHEMBL31377731 0.75 GRM2 (0.36) MAOB
SCHEMBL25367772 0.72 ALDH1A1 (0.41) ALDH1A1TSHRHPGDMEN1GAA
SCHEMBL25367287 0.72 PPARD (0.40) ALDH1A1HPGDMEN1GAAMAPT
SCHEMBL22727903 0.71 ALDH1A1 (0.42) ALDH1A1TSHRHPGDMEN1GAA
SCHEMBL22727904 0.71 ALDH1A1 (0.40) ALDH1A1TSHRHPGDMEN1GAA
SCHEMBL18322124 0.70 NPC1 (0.48) ALDH1A1HPGDTDP1CYP2A6PTGER4
SCHEMBL25368354 0.70 PPARD (0.39) ALDH1A1HPGDMEN1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012026403-A1 CONDENSED RING COMPOUND 日本曹達株式会社 (JP) 2012-03-01 WO disclosed