Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248217 | 1.00 | HTT (0.54) | HTTALDH1A1ALOX12NPSR1TDP1 | |
| SCHEMBL14815168 | 1.00 | HTT (0.54) | HTTALDH1A1ALOX12NPSR1TDP1 | |
| SCHEMBL9656136 | 0.81 | HTT (0.57) | HTTALDH1A1ALOX12NPSR1TDP1 | |
| SCHEMBL9262162 | 0.77 | HTT (0.34) | HTTALDH1A1ALOX12NPSR1TDP1 | |
| SCHEMBL9262166 | 0.77 | HTT (0.34) | HTTALDH1A1ALOX12NPSR1TDP1 | |
| SCHEMBL10372413 | 0.76 | DAO (0.50) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL17988367 | 0.76 | DAO (0.50) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL9911082 | 0.76 | DAO (0.50) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL11256478 | 0.74 | ALDH1A1 (0.54) | HTTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL640603 | 0.74 | F2 (0.59) | HTTALDH1A1ALOX12NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358907-B2 | Substituted pyrrolidine amides III | Grünenthal GmbH (DE) | 2025-07-15 | — | — | US | disclosed |
| CN-113382990-B | Substituted pyrrolidinamide III | 格吕伦塔尔有限公司 | 2024-11-19 | — | — | CN | disclosed |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2022-03-24 | — | — | US | disclosed |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2022-03-24 | — | — | US | disclosed |
| EP-3908581-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2021-11-17 | — | — | EP | disclosed |
| CN-113382990-A | Substituted pyrrolidine amides III | 格吕伦塔尔有限公司 | 2021-09-10 | — | — | CN | disclosed |
| WO-2020144375-A9 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020144375-A9 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2020-10-29 | — | — | WO | disclosed |
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | GRUENENTHAL GMBH (DE) | 2020-07-16 | — | — | US | disclosed |
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | GRUENENTHAL GMBH (DE) | 2020-07-16 | — | — | US | disclosed |
| US-8759371-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759371-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-24 | — | — | US | disclosed |
| EP-2588468-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC (US) | 2014-03-26 | — | — | EP | disclosed |
| EP-2588468-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC (US) | 2014-03-26 | — | — | EP | disclosed |
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130085151-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085151-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085151-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12358907-B2 | Substituted pyrrolidine amides III | NR3C1, NR3C2, MC2R | HTT 3853/4885ALDH1A1 1199/4885ALOX12 1729/4885 |
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | HTT 3853/4885ALDH1A1 1199/4885ALOX12 1729/4885 |
| US-20130085151-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | HTT 1044/4885ALDH1A1 3735/4885ALOX12 361/4885 |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | HTT 3853/4885ALDH1A1 1199/4885ALOX12 1729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.