Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24711530 | 0.88 | DRD2 (0.36) | DRD2PIK3CD | |
| SCHEMBL12735346 | 0.82 | PIK3CD (0.33) | GAAPIK3CD | |
| SCHEMBL8260056 | 0.78 | HTR2A (0.39) | NOTUMPIK3CD | |
| SCHEMBL12267884 | 0.78 | HTR2A (0.39) | NOTUMPIK3CD | |
| SCHEMBL14329347 | 0.78 | HTR2A (0.39) | NOTUMPIK3CD | |
| SCHEMBL2659902 | 0.77 | TACR1 (0.48) | DRD2 | |
| SCHEMBL20522860 | 0.77 | TACR1 (0.48) | DRD2 | |
| SCHEMBL15451877 | 0.77 | LTA4H (0.41) | DRD2GAA | |
| SCHEMBL21214334 | 0.76 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL21739463 | 0.75 | PDCD1LG2 (0.41) | DRD2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022261243-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | Epizyme, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |