Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 7/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465374 | 0.88 | MEN1 (0.54) | MEN1KMT2ATP53METDAO | |
| SCHEMBL2464399 | 0.87 | MET (0.52) | MEN1KMT2ATP53METDAO | |
| SCHEMBL2469745 | 0.80 | MET (0.60) | MEN1KMT2AMET | |
| SCHEMBL2464345 | 0.73 | MEN1 (0.52) | MEN1KMT2AMET | |
| SCHEMBL15815830 | 0.72 | SLC22A12 (0.43) | MEN1KMT2ATP53METDAO | |
| SCHEMBL3063362 | 0.69 | MET (0.79) | MEN1KMT2AMET | |
| SCHEMBL23297363 | 0.69 | MEN1 (0.80) | MEN1KMT2ATP53 | |
| SCHEMBL20530338 | 0.69 | MET (0.42) | TOP1METSLC22A12 | |
| SCHEMBL23297225 | 0.69 | MEN1 (0.84) | MEN1KMT2ATP53 | |
| SCHEMBL20530291 | 0.68 | PARP1 (0.38) | METSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | disclosed |