Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464399 | 0.90 | MET (0.52) | MEN1KMT2ATP53DAOMET | |
| SCHEMBL2471206 | 0.88 | MEN1 (0.51) | MEN1KMT2ATP53DAOMET | |
| SCHEMBL23297225 | 0.79 | MEN1 (0.84) | MEN1KMT2ATP53HDAC1KDM4E | |
| SCHEMBL2465372 | 0.77 | MET (0.65) | MEN1KMT2ATP53METHDAC1 | |
| SCHEMBL20530302 | 0.76 | MET (0.51) | MEN1KMT2AMETKDM4EALDH1A1 | |
| SCHEMBL15815830 | 0.75 | SLC22A12 (0.43) | MEN1KMT2ATP53DAOMET | |
| SCHEMBL23297309 | 0.74 | HDAC1 (0.61) | MEN1KMT2ATP53HDAC1KDM4E | |
| SCHEMBL23297367 | 0.73 | MEN1 (0.60) | MEN1KMT2ATP53METHDAC1 | |
| SCHEMBL29776793 | 0.73 | MEN1 (0.60) | MEN1KMT2ATP53METHDAC1 | |
| SCHEMBL14028970 | 0.71 | MEN1 (0.55) | MEN1KMT2ATP53METHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | disclosed |