Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465374 | 0.90 | MEN1 (0.54) | METMEN1KMT2ATP53DAO | |
| SCHEMBL2471206 | 0.87 | MEN1 (0.51) | METMEN1KMT2ATP53DAO | |
| SCHEMBL2464398 | 0.79 | MET (0.62) | MET | |
| SCHEMBL2468829 | 0.78 | MET (0.50) | METMEN1KMT2ATP53 | |
| SCHEMBL15815830 | 0.74 | SLC22A12 (0.43) | METMEN1KMT2ATP53DAO | |
| SCHEMBL2471194 | 0.74 | MET (0.61) | METTP53 | |
| SCHEMBL1151179 | 0.73 | MET (0.54) | METMEN1KMT2ATP53 | |
| SCHEMBL2466706 | 0.73 | MET (0.58) | METMEN1KMT2ATP53 | |
| SCHEMBL2466743 | 0.71 | MET (0.65) | METMEN1KMT2A | |
| SCHEMBL1952616 | 0.71 | MET (0.65) | METMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | disclosed |
| EP-1960370-A1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | Merck Patent GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007065518-A1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |