Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 3/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12250688 | 0.88 | ATM (0.42) | MMEACEACE2KMT2AMAPT | |
| SCHEMBL25070788 | 0.86 | NPC1 (0.47) | MMEACECPA1ACE2KMT2A | |
| SCHEMBL953389 | 0.84 | FOLH1 (0.56) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL29163852 | 0.84 | ACE (0.49) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL16863786 | 0.84 | ESR1 (0.51) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL838885 | 0.84 | FOLH1 (0.56) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL2058952 | 0.83 | ESR1 (0.58) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL21282538 | 0.83 | ESR1 (0.58) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL12250719 | 0.83 | ESR1 (0.46) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL2058953 | 0.83 | ESR1 (0.58) | FOLH1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | Universite De Paris (FR) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | CASP2, CASP1, CASP3 | FOLH1 249/4885MME 1605/4885ACE 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.