SCHEMBL24716239

SCHEMBL24716239

Clc1ccc2ccnc(Cl)c2n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.38
CYP3A4 P08684 2/20 0.38
MAPT P10636 2/20 0.38
PMP22 Q01453 2/20 0.38
APEX1 P27695 1/20 0.38
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GMNN O75496 1/20 0.36
TP53 P04637 1/20 0.36
HSP90AA1 P07900 1/20 0.36
MMP2 P08253 1/20 0.36
CYP2D6 P10635 1/20 0.36
MMP9 P14780 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
NFKB1 P19838 1/20 0.36
MMP8 P22894 1/20 0.36
CCR1 P32246 1/20 0.36
THPO P40225 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30670499 1.00 LMNA (0.38) LMNACYP3A4MAPTPMP22APEX1
SCHEMBL29772209 0.83 NCF1 (0.42) LMNACYP3A4MAPTPMP22APEX1
SCHEMBL17318142 0.78 LMNA (0.36) LMNACYP3A4MAPTPMP22APEX1
SCHEMBL3380746 0.78 MAPT (0.33) LMNACYP3A4MAPTPMP22TDP1
SCHEMBL16463280 0.78 NOS3 (0.41) LMNACYP3A4MAPTPMP22TDP1
SCHEMBL3378802 0.78 CCR1 (0.56) LMNACYP3A4MAPTPMP22APEX1
SCHEMBL29533844 0.77 CCR1 (0.43) LMNACYP3A4MAPTPMP22TDP1
SCHEMBL557084 0.77 CCR1 (0.43) LMNACYP3A4MAPTPMP22TDP1
SCHEMBL31105908 0.75 CCR1 (0.63) LMNACYP3A4MAPTPMP22APEX1
SCHEMBL23169319 0.74 MCHR1 (0.36) CYP3A4MAPTMAPK1KDM4ECYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015352-A1 METHYLTRANSFERASE INHIBITOR AND USE THEREOF CYTOSINLAB THERAPEUTICS CO LTD (CN) 2026-01-15 US disclosed
WO-2024012461-A1 METHYLTRANSFERASE INHIBITOR AND USE THEREOF 上海赛岚生物科技有限公司 2024-01-18 WO disclosed
CN-117384153-A Methyltransferase inhibitors and uses thereof 上海赛岚生物科技有限公司 2024-01-12 CN disclosed
EP-2903978-B1 GDF-8 INHIBITORS RIGEL PHARMACEUTICALS INC (US) 2022-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015352-A1 METHYLTRANSFERASE INHIBITOR AND USE THEREOF EZH2, DOT1L, EHMT1 LMNA 1434/4885CYP3A4 1386/4885MAPT 2823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.