Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.69 |
| ▸ | INSR | P06213 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716360 | 0.89 | ALK (0.73) | ALKINSRKCNH2MET | |
| SCHEMBL29102656 | 0.85 | MAP4K1 (0.51) | ALKINSRMET | |
| SCHEMBL24716364 | 0.85 | MAP4K1 (0.68) | ALKINSR | |
| SCHEMBL18759906 | 0.82 | ALK (1.00) | ALKINSR | |
| SCHEMBL18759939 | 0.82 | ALK (1.00) | ALKINSR | |
| SCHEMBL24716012 | 0.81 | ALK (0.62) | ALKINSRKCNH2MET | |
| SCHEMBL24716309 | 0.81 | ALK (0.58) | ALK | |
| SCHEMBL24716377 | 0.80 | ALK (0.60) | ALKINSRMET | |
| SCHEMBL24716293 | 0.80 | ALK (0.71) | ALKINSRMET | |
| SCHEMBL29869922 | 0.80 | ALK (0.71) | ALKINSRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |