Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718829 | 1.00 | HDAC11 (0.42) | HDAC11CRHR1SIRT2SIRT1TMPRSS4 | |
| SCHEMBL24718262 | 0.85 | ALDH1A1 (0.43) | SIGMAR1CCR2 | |
| SCHEMBL24718382 | 0.81 | TP53 (0.46) | HDAC11CRHR1SIRT2SIRT1TMPRSS4 | |
| SCHEMBL24718416 | 0.81 | TP53 (0.46) | HDAC11CRHR1SIRT2SIRT1TMPRSS4 | |
| SCHEMBL24718241 | 0.81 | TP53 (0.46) | HDAC11CRHR1SIRT2SIRT1TMPRSS4 | |
| SCHEMBL24718433 | 0.80 | CRHR1 (0.41) | CRHR1SIRT2SIRT1P2RX7CRHR2 | |
| SCHEMBL24718259 | 0.80 | SRC (0.43) | HDAC11SIRT2SIRT1TMPRSS4EPHX2 | |
| SCHEMBL24718281 | 0.78 | TP53 (0.46) | HDAC11SIRT2SIRT1SCN9AEPHX2 | |
| SCHEMBL24718261 | 0.76 | P2RX7 (0.41) | HDAC11SIRT2SIRT1TMPRSS4EPHX2 | |
| SCHEMBL24718415 | 0.75 | TP53 (0.49) | HDAC11SIRT2SIRT1TMPRSS4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | HDAC11 224/4885CRHR1 3326/4885SIRT2 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.