Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 2/20 | 0.45 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24719132 | 0.85 | MEN1 (0.43) | DRD4DRD2HTR2AKDM4E | |
| SCHEMBL24718656 | 0.85 | MEN1 (0.43) | DRD4DRD2HTR2AKDM4E | |
| SCHEMBL24718430 | 0.81 | P2RX1 (0.45) | P2RX1TMPRSS4CCR2DRD4HSP90AA1 | |
| SCHEMBL24718823 | 0.81 | P2RX1 (0.45) | P2RX1TMPRSS4CCR2DRD4HSP90AA1 | |
| SCHEMBL24460414 | 0.68 | P2RX1 (0.80) | P2RX1TMPRSS4HTR2AP2RX4P2RX7 | |
| SCHEMBL24718415 | 0.66 | TP53 (0.49) | P2RX1TMPRSS4P2RX7KDM4EALDH1A1 | |
| SCHEMBL24718657 | 0.66 | SMN1; SMN2 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL24719133 | 0.66 | SMN1; SMN2 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL24719112 | 0.66 | SMN1; SMN2 (0.44) | KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL31571888 | 0.64 | TAS1R3 (0.49) | P2RX1TMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | P2RX1 4064/4885TMPRSS4 3201/4885CCR2 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.