Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MITF | O75030 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128754 | 0.92 | MAPT (0.52) | HTTKMT2ATSHRMAPTL3MBTL1 | |
| SCHEMBL6663091 | 0.89 | MAPT (0.52) | GPR35TSHRMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1248698 | 0.88 | GRM5 (0.53) | HTTKMT2AGPR35MAPTL3MBTL1 | |
| SCHEMBL1248699 | 0.88 | GRM5 (0.53) | HTTKMT2AGPR35MAPTL3MBTL1 | |
| SCHEMBL1274938 | 0.82 | HTT (0.73) | HTTKMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1247295 | 0.81 | MAPT (0.59) | KMT2AMAPTL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1926046 | 0.77 | TSHR (0.71) | KMT2AGPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL118464 | 0.77 | TSHR (0.71) | KMT2AGPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9059478 | 0.76 | CTSB (0.56) | KMT2AMAPTL3MBTL1ALDH1A1MITF | |
| SCHEMBL29937743 | 0.76 | CTSB (0.65) | HTTKMT2AMAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017835-A4 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | UNIV BOSTON (US) | 2005-01-26 | — | — | EP | claimed |
| US-6207648-B1 | USE OF NADPH-CYTOCHROME P450 REDUCTASE GENE TRANSFER IN COMBINATION WITH CYTOCHROME P450 GENE TRANSFER TO ENHANCE THE SENSITIVITY OF TUMOR CELLS TO ANTI-CANCER DRUGS THAT ARE ACTIVATED BY P450 ENZYMES | TRUSTEES OF BOSTON UNIVERSITY | 2001-03-27 | — | — | US | claimed |
| EP-1017835-A1 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | Trustees of Boston University (US) | 2000-07-12 | — | — | EP | claimed |
| WO-1999005299-A1 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | TRUSTEES OF BOSTON UNIVERSITY (US) | 1999-02-04 | — | — | WO | claimed |
| EP-1017835-B1 | CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | UNIV BOSTON (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-1017835-A4 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | UNIV BOSTON (US) | 2005-01-26 | — | — | EP | disclosed |
| US-6207648-B1 | USE OF NADPH-CYTOCHROME P450 REDUCTASE GENE TRANSFER IN COMBINATION WITH CYTOCHROME P450 GENE TRANSFER TO ENHANCE THE SENSITIVITY OF TUMOR CELLS TO ANTI-CANCER DRUGS THAT ARE ACTIVATED BY P450 ENZYMES | TRUSTEES OF BOSTON UNIVERSITY | 2001-03-27 | — | — | US | disclosed |
| EP-1017835-A1 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | Trustees of Boston University (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999005299-A1 | METHODS OF USING CYTOCHROME P450 REDUCTASE FOR THE ENHANCEMENT OF P450-BASED ANTI-CANCER GENE THERAPY | TRUSTEES OF BOSTON UNIVERSITY (US) | 1999-02-04 | — | — | WO | disclosed |