Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1248699 | 1.00 | GRM5 (0.53) | GRM5KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL2471909 | 0.88 | HTT (0.54) | GRM5KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL4526192 | 0.87 | GRM5 (0.67) | GRM5KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL28744241 | 0.86 | ALDH1A1 (0.51) | KMT2AMEN1L3MBTL1LMNAMAPT | |
| SCHEMBL1247295 | 0.82 | MAPT (0.59) | GRM5KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL12128754 | 0.81 | MAPT (0.52) | KMT2AL3MBTL1LMNAMAPTHTT | |
| SCHEMBL6663091 | 0.78 | MAPT (0.52) | LMNAMAPTGPR35ALDH1A1MAPK1 | |
| SCHEMBL27955986 | 0.77 | MAPT (0.52) | GRM5KMT2AMEN1LMNAMAPT | |
| SCHEMBL4971357 | 0.76 | MAPT (0.48) | KMT2AMEN1L3MBTL1MAPTHTT | |
| SCHEMBL3624869 | 0.76 | CTSB (0.69) | GRM5KMT2AMEN1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285784-B1 | 2-METHYL-1-(PHENYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE AS 5-HYDROXYTRYPTAMINE-6 LIGAND | WYETH LLC (US) | 2012-07-04 | — | — | EP | disclosed |
| US-8063053-B2 | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazoles as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2011-11-22 | — | — | US | disclosed |
| EP-2285784-A1 | 1-(ARYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth LLC (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2010056644-A1 | 1- (ARYLSULFONYL) -4- (PI PERAZIN-I -YL) -IH-BENZ IMIDAZOLES AS δ-HYDROXYTRYPTAMINE- 6 LIGANDS | WYETH LLC (US) | 2010-05-20 | — | — | WO | disclosed |
| US-20100120779-A1 | 1-(ARYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120779-A1 | 1-(ARYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | HTR6, TPH1, HTR4 | GRM5 76/4885KMT2A 1987/4885MEN1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.