Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718433 | 0.88 | CRHR1 (0.41) | CCR2SIRT1CRHR1CRHR2KMT2A | |
| SCHEMBL24718848 | 0.81 | P2RX7 (0.41) | SIRT1CRHR1KMT2ADRD4RAB9A | |
| SCHEMBL24718431 | 0.80 | P2RX7 (0.42) | SIRT1KMT2ARAB9AACSS2 | |
| SCHEMBL24718416 | 0.79 | TP53 (0.46) | SIRT1CRHR1CRHR2KMT2ADRD4 | |
| SCHEMBL24718425 | 0.79 | SIRT1 (0.43) | SIRT1KMT2ARAB9A | |
| SCHEMBL24718241 | 0.79 | TP53 (0.46) | SIRT1CRHR1CRHR2KMT2ADRD4 | |
| SCHEMBL24718382 | 0.79 | TP53 (0.46) | SIRT1CRHR1CRHR2KMT2ADRD4 | |
| SCHEMBL24718427 | 0.78 | TMPRSS4 (0.45) | KMT2ARAB9A | |
| SCHEMBL24718281 | 0.75 | TP53 (0.46) | SIRT1KMT2ARAB9AACSS2 | |
| SCHEMBL24718257 | 0.73 | TEAD1 (0.52) | KMT2ADRD4RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | CCR2 3257/4885SIRT1 864/4885CRHR1 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.