Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.42 |
| ▸ | KCNB1 | Q14721 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13801391 | 0.92 | PDPK1 (0.55) | PDPK1LOXL2RXRARXRBRXRG | |
| SCHEMBL11994379 | 0.82 | PDPK1 (0.57) | PDPK1LOXL2ADRB2CYP2A6SLC6A4 | |
| SCHEMBL29793545 | 0.80 | PDPK1 (0.51) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL27992983 | 0.80 | PDPK1 (0.51) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL28405984 | 0.80 | PDPK1 (0.51) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL5888543 | 0.80 | PDPK1 (0.51) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL23601602 | 0.80 | PDPK1 (0.59) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL24227164 | 0.78 | PDPK1 (0.49) | PDPK1LOXL2ADRB2CYP2A6CTSA | |
| SCHEMBL5147639 | 0.76 | PDPK1 (0.91) | PDPK1LOXL2ADRB2CYP2A6SLC6A4 | |
| SCHEMBL598181 | 0.76 | RXRA (0.66) | RXRARXRBRXRGPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | PDPK1 8/4885LOXL2 1787/4885RXRA 1414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.