Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13231660 | 0.81 | PIK3CD (0.47) | HPGDSPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL6120463 | 0.79 | PTGS2 (0.56) | IDO1 | |
| SCHEMBL2757248 | 0.78 | MAP4K4 (0.46) | IDO1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24721381 | 0.77 | MAP4K4 (0.59) | IDO1SYKTGFBR1MAP4K4ADORA2A | |
| SCHEMBL10165304 | 0.77 | TAAR1 (0.50) | IDO1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL12947919 | 0.76 | IDO1 (0.46) | IDO1SYKTGFBR1HSD17B1HSD17B2 | |
| SCHEMBL4582712 | 0.75 | PIK3CD (0.43) | HPGDSPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL21228152 | 0.75 | HSD17B2 (0.66) | HSD17B1HSD17B2 | |
| SCHEMBL13624520 | 0.75 | CYP2A6 (0.56) | MAP4K4 | |
| SCHEMBL422044 | 0.75 | SMN1; SMN2 (0.55) | IDO1MAP4K4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | IDO1 3054/4885HPGDS 444/4885PIK3CD 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.