Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24721275 | 0.78 | IDO1 (0.45) | MAP4K4IDO1SYKTGFBR1 | |
| SCHEMBL24721532 | 0.77 | IDO1 (0.47) | MAP4K4IDO1SYKADORA2AADORA1 | |
| SCHEMBL3804537 | 0.77 | MAOA (0.56) | MAP4K4IDO1 | |
| SCHEMBL3786065 | 0.76 | TAAR1 (0.52) | IDO1BACE1 | |
| SCHEMBL13040 | 0.76 | MAP4K4 (0.66) | MAP4K4IDO1ADORA1 | |
| SCHEMBL11613189 | 0.75 | RAB9A (0.61) | IDO1ADORA2AADORA1BACE1ABCG2 | |
| SCHEMBL2643156 | 0.75 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL3480820 | 0.74 | IDO1 (0.50) | IDO1SYKABCG2ABCC1ABCB1 | |
| SCHEMBL30849630 | 0.74 | IDO1 (0.50) | IDO1SYKABCG2ABCC1ABCB1 | |
| SCHEMBL13606218 | 0.73 | AOC3 (0.50) | IDO1BACE1DHFRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | MAP4K4 236/4885IDO1 3054/4885SYK 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.