Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19629265 | 0.82 | TSHR (0.42) | TSHRRORCPDE2AF2RL1CES2 | |
| SCHEMBL2737293 | 0.79 | GABRA1 (0.50) | TSHRADRB2ADRB1ADRB3ADRA2A | |
| SCHEMBL14457121 | 0.78 | TSHR (0.39) | TSHRRORCPDE2AF2RL1CES2 | |
| SCHEMBL26860328 | 0.77 | TSHR (0.38) | TSHRRORCPDE2AF2RL1 | |
| SCHEMBL20621222 | 0.77 | TSHR (0.57) | TSHRRORCADRB1ADRB3ADRA2A | |
| SCHEMBL21767240 | 0.75 | TSHR (0.54) | TSHRRORCADRA1AUSP2ALDH1A1 | |
| SCHEMBL17429416 | 0.74 | TSHR (0.53) | TSHRRORCADRB2ADRB1ADRB3 | |
| SCHEMBL16117022 | 0.74 | TSHR (0.44) | TSHRRORCADRB2ADRB1ADRB3 | |
| SCHEMBL2382143 | 0.74 | TSHR (0.57) | TSHRRORCADRB2ADRB1ADRB3 | |
| SCHEMBL20097032 | 0.73 | TSHR (0.38) | TSHRRORCPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256676-A1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |