Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.37 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26123338 | 0.77 | PRF1 (0.56) | PRF1LMNAKCNH2ALDH1A1GAA | |
| SCHEMBL24427973 | 0.77 | LMNA (0.54) | LMNAALDH1A1GAATSHRMAPT | |
| SCHEMBL25184590 | 0.76 | CYP11B1 (0.47) | PDE3BPDE3ACYP11B1CYP11B2SMYD3 | |
| SCHEMBL24726554 | 0.76 | SMYD3 (0.38) | SMYD3LMNAALDH1A1CYP2C9ALOX15 | |
| SCHEMBL14815941 | 0.74 | PDE3B (0.54) | PDE3BPDE3AALDH1A1GAAMAPT | |
| SCHEMBL25845703 | 0.74 | SIRT2 (0.48) | PDE3BPDE3ACYP11B1CYP11B2SMYD3 | |
| SCHEMBL434348 | 0.73 | CYP11B1 (0.51) | PDE3BPDE3ACYP11B1CYP11B2KCNH2 | |
| SCHEMBL25190549 | 0.72 | LMNA (0.32) | PDE3BPDE3ALMNATSHR | |
| SCHEMBL4395266 | 0.72 | CYP11B1 (0.46) | PDE3BPDE3ACYP11B1CYP11B2SMYD3 | |
| SCHEMBL2056370 | 0.72 | PARP1 (0.51) | PDE3BPDE3ACYP11B1CYP11B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD. (CN) | 2022-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | TFPI, TFPI2, F11 | PDE3B 2430/4885PDE3A 2189/4885CYP11B1 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.