Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 11/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FSHR | P23945 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729482 | 0.89 | KLKB1 (0.40) | KLKB1DGAT1METTL3TSHRFSHR | |
| SCHEMBL29927020 | 0.89 | KLKB1 (0.40) | KLKB1DGAT1METTL3TSHRFSHR | |
| SCHEMBL24729494 | 0.84 | KLKB1 (0.39) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL24729593 | 0.82 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL29879153 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL29136815 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL29136754 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL24739072 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL29136756 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF | |
| SCHEMBL27957767 | 0.82 | DGAT1 (0.42) | KLKB1DGAT1METTL3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308227-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |