Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 17/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737728 | 0.87 | ACVRL1 (0.48) | METTL3KLKB1 | |
| SCHEMBL24739071 | 0.87 | METTL3 (0.43) | METTL3KLKB1 | |
| SCHEMBL24729704 | 0.85 | METTL3 (0.44) | METTL3KLKB1KDM4ETP53 | |
| SCHEMBL24729594 | 0.85 | METTL3 (0.44) | METTL3KLKB1TP53MEN1NPC1 | |
| SCHEMBL24739070 | 0.85 | KLKB1 (0.44) | METTL3KLKB1 | |
| SCHEMBL24729468 | 0.85 | METTL3 (0.44) | METTL3KLKB1MEN1NPC1ALDH1A1 | |
| SCHEMBL24729668 | 0.81 | METTL3 (0.39) | METTL3KLKB1KDM4ENPC1RAB9A | |
| SCHEMBL24737727 | 0.79 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL29880319 | 0.79 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL29141747 | 0.79 | METTL3 (0.44) | METTL3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |