Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389196 | 0.81 | FAAH (0.44) | KMT2APARP10PPARGPPARAPOLB | |
| SCHEMBL2387999 | 0.76 | KMT2A (0.55) | KMT2APARP10PPARGPPARAPOLB | |
| SCHEMBL13651984 | 0.65 | KMT2A (0.47) | KMT2APARP10POLBALDH1A1ACACB | |
| SCHEMBL21003709 | 0.64 | ALDH1A3 (0.47) | KMT2APARP10POLBALDH1A1ACACB | |
| SCHEMBL12480922 | 0.64 | ALDH1A3 (0.47) | KMT2APARP10POLBALDH1A1ACACB | |
| SCHEMBL27579668 | 0.63 | KMT2A (0.60) | KMT2APARP10POLBALDH1A1GLA | |
| SCHEMBL11002192 | 0.63 | KMT2A (0.60) | KMT2APARP10PPARGPPARAPOLB | |
| SCHEMBL9034923 | 0.63 | PTGS2 (0.55) | KMT2APARP10MMP3ALDH1A3 | |
| Hydrogen Peroxide SCHEMBL28902806 | 0.62 | KMT2A (0.70) | KMT2APARP10POLBALDH1A1GLA | |
| SCHEMBL125543 | 0.62 | ALDH1A3 (0.64) | KMT2APARP10POLBALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544679-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112828-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |