Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212429 | 0.77 | HTR1B (0.58) | HTR1BSMN1; SMN2TAAR1MAPK1KDM4E | |
| SCHEMBL14853454 | 0.76 | BACE1 (0.43) | GLASMN1; SMN2TAAR1TSHRMAPK1 | |
| SCHEMBL18906416 | 0.72 | ELANE (0.49) | SMN1; SMN2TSHRMAPK1TTR | |
| SCHEMBL13842107 | 0.72 | KCNA3 (0.47) | TSHR | |
| SCHEMBL13842094 | 0.72 | KCNA3 (0.47) | — | |
| SCHEMBL3977247 | 0.72 | L3MBTL1 (0.41) | CYP4F2CYP4A11KDM4E | |
| SCHEMBL20200250 | 0.72 | PDCD1 (0.51) | CYP4F2CYP4A11TAAR1TSHRMAPK1 | |
| SCHEMBL31280574 | 0.72 | PDCD1 (0.51) | CYP4F2CYP4A11TAAR1TSHRMAPK1 | |
| SCHEMBL9965339 | 0.72 | HRH3 (0.53) | TAAR1 | |
| SCHEMBL14852986 | 0.71 | PYGL (0.41) | CYP4F2CYP4A11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371827-A1 | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use | SANOFI (FR) | 2011-10-05 | — | — | EP | disclosed |