Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195085 | 0.83 | CYP3A4 (0.48) | USP30JAK2JAK1MEN1KMT2A | |
| SCHEMBL11092491 | 0.75 | OPRM1 (0.60) | KMT2ATSHR | |
| SCHEMBL2778584 | 0.73 | L3MBTL1 (0.38) | KITRORCPTGDR2MEN1KMT2A | |
| SCHEMBL28691096 | 0.73 | OPRM1 (0.39) | USP30KMT2A | |
| SCHEMBL6963424 | 0.73 | MEN1 (0.46) | JAK2JAK1MEN1KMT2A | |
| SCHEMBL29995192 | 0.71 | GPR119 (0.44) | HRH1JAK2JAK1ADRA1DADRA1A | |
| SCHEMBL7527349 | 0.71 | GPR119 (0.44) | HRH1JAK2JAK1ADRA1DADRA1A | |
| SCHEMBL2779561 | 0.70 | GPR119 (0.43) | JAK2JAK1KMT2A | |
| SCHEMBL28597678 | 0.70 | USP30 (0.46) | USP30JAK2JAK1RORC | |
| SCHEMBL31415651 | 0.69 | MEN1 (0.44) | JAK2JAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370423-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | Glaxo Group Limited (GB) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065704-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |
| EP-2166848-A1 | SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS | Glaxo Group Limited (GB) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008157741-A1 | SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-12-24 | — | — | WO | disclosed |