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SCHEMBL24744701

SCHEMBL24744701

Cc1cc(OCCCc2c(C(=O)OC(C)(C)C)n(C)c3c(-c4c(C)nn(CCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)c4C)cccc23)cc(C)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PDE6D O43924 8/20 0.50
▸ GRAMD1A Q96CP6 5/20 0.48
▸ DDB1 Q16531 1/20 0.47
▸ CRBN Q96SW2 1/20 0.47
▸ STAT3 P40763 3/20 0.45
▸ EGFR P00533 3/20 0.43
▸ ERBB2 P04626 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24745279 0.93 PDE6D (0.52) PDE6DSTAT3EGFRERBB2
SCHEMBL24745172 0.92 PDE6D (0.46) PDE6DGRAMD1ADDB1CRBNSTAT3
SCHEMBL24744702 0.89 PDE6D (0.50) PDE6DSTAT3EGFRERBB2
SCHEMBL30000785 0.87 DDB1 (0.45) PDE6DGRAMD1ADDB1CRBN
SCHEMBL24744714 0.87 DDB1 (0.45) PDE6DGRAMD1ADDB1CRBN
SCHEMBL30000748 0.86 GRAMD1A (0.45) PDE6DGRAMD1ADDB1CRBNSTAT3
SCHEMBL24744722 0.86 GRAMD1A (0.45) PDE6DGRAMD1ADDB1CRBNSTAT3
SCHEMBL24744625 0.86 MCL1 (0.49) PDE6D
SCHEMBL24744743 0.83 MCL1 (0.49) DDB1CRBN
SCHEMBL24745677 0.83 PDE6D (0.45) PDE6DGRAMD1ASTAT3EGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022255888-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2022-12-08 — — WO disclosed
WO-2022255888-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2022-12-08 — — WO disclosed
WO-2022253713-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2022-12-08 — — WO disclosed