Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 6/20 | 0.60 |
| ▸ | QPCTL | Q9NXS2 | 4/20 | 0.60 |
| ▸ | PRKCI | P41743 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634290 | 0.92 | QPCT (0.68) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL31143361 | 0.92 | MAPT (0.50) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL6008269 | 0.92 | MAPT (0.50) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL2462345 | 0.82 | QPCT (0.68) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL2457365 | 0.82 | QPCT (0.50) | QPCTQPCTLKDM4EMAPTALDH1A1 | |
| SCHEMBL17283574 | 0.82 | QPCT (0.51) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL13373486 | 0.81 | PARP1 (0.46) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL7021134 | 0.81 | QPCT (0.49) | QPCTQPCTLKDM4EMAPTALDH1A1 | |
| SCHEMBL38665709 | 0.81 | QPCT (0.66) | QPCTQPCTLPRKCIKDM4EMAPT | |
| SCHEMBL7021141 | 0.81 | QPCT (0.66) | QPCTQPCTLPRKCIKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2907813-B1 | Antibacterial pharmaceutical compositions | SUMMIT THERAPEUTICS PLC (GB) | 2016-04-27 | — | — | EP | claimed |
| US-9314456-B2 | Antibacterial compounds | SUMMIT THERAPEUTICS PLC (GB) | 2016-04-19 | — | — | US | claimed |
| EP-3095783-A1 | ANTIBACTERIAL COMPOUNDS | Summit Corporation Plc (GB) | 2016-11-23 | — | — | EP | disclosed |
| EP-3011960-A1 | COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASE | Summit Therapeutics plc (GB) | 2016-04-27 | — | — | EP | disclosed |
| WO-2011151620-A1 | COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE | SUMMIT CORPORATION PLC (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151618-A2 | COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASE | SUMMIT CORPORATION PLC (GB) | 2011-12-08 | — | — | WO | disclosed |
| EP-2373631-A2 | ANTIBACTERIAL COMPOUNDS | Summit Corporation Plc (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010063996-A2 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORPORATION PLC (GB) | 2010-06-10 | — | — | WO | disclosed |