Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30000721 | 1.00 | PTGDR2 (0.50) | PTGDR2KDM4EHPGDPKN1PKN2 | |
| SCHEMBL7485320 | 0.84 | NPSR1 (0.44) | KDM4EHPGDPKN1PKN2PTGER4 | |
| SCHEMBL29893726 | 0.84 | PKN1 (0.47) | PTGDR2KDM4EPKN1PKN2PIK3CB | |
| SCHEMBL24744762 | 0.84 | PKN1 (0.47) | PTGDR2KDM4EPKN1PKN2PIK3CB | |
| SCHEMBL24746679 | 0.80 | THRB (0.46) | PTGDR2KDM4EHSD17B10ATMAKR1B10 | |
| SCHEMBL3164934 | 0.79 | KDM4E (0.46) | KDM4EHSD17B10LMNATSHRHTT | |
| SCHEMBL7477385 | 0.79 | PARP1 (0.49) | KDM4EPKN1PKN2PIK3CBMAPT | |
| SCHEMBL31498298 | 0.78 | MAPT (0.45) | KDM4EPKN1PKN2PIK3CBMAPT | |
| SCHEMBL24745731 | 0.77 | KDM4E (0.42) | KDM4EHPGDPKN1PKN2PTGER4 | |
| SCHEMBL24744939 | 0.77 | SMN1; SMN2 (0.41) | KDM4EPKN1PKN2PIK3CBPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |