Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24746474 | 0.84 | CHRNB2 (0.38) | PIK3CAMTORCHRNB2CHRNA4ACACB | |
| SCHEMBL14913101 | 0.82 | CHRNB2 (0.42) | PIK3CAMTORCHRNB2CHRNA4TRPC6 | |
| SCHEMBL7039004 | 0.81 | MAPT (0.40) | PIK3CAMTORACACB | |
| SCHEMBL25558377 | 0.76 | CHRNB2 (0.42) | CHRNB2CHRNA4TRPC6CHRNB4CHRNA3 | |
| SCHEMBL24177865 | 0.75 | CHRNB2 (0.40) | CHRNB2CHRNA4TRPC6ACACBCHRNB4 | |
| SCHEMBL2792128 | 0.75 | PIK3CA (0.49) | PIK3CAMTORCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL7035423 | 0.75 | RAD52 (0.47) | PIK3CAMTORACACBRET | |
| SCHEMBL1393583 | 0.74 | MAPT (0.49) | PIK3CAMTORCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22441718 | 0.73 | PIK3CA (0.56) | PIK3CAMTORTRPC6 | |
| SCHEMBL17796563 | 0.73 | MAP4K4 (0.50) | PIK3CAMTORCHRNB2CHRNA4TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120090-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |