Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24745829 | 0.84 | PIK3CA (0.45) | CHRNB2CHRNA4ACACBCHRNB4CHRNA3 | |
| SCHEMBL7039004 | 0.76 | MAPT (0.40) | ACACBPIK3CAMTORLIPCLIPG | |
| SCHEMBL24746029 | 0.76 | PIK3CA (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA | |
| SCHEMBL7035423 | 0.73 | RAD52 (0.47) | ACACBPIK3CAMTORLIPCLIPG | |
| SCHEMBL27854325 | 0.73 | MAPT (0.50) | CHRNB2CHRNA4ELANECHRNB4CHRNA3 | |
| SCHEMBL10154840 | 0.72 | ELANE (0.44) | CHRNB2CHRNA4ELANECHRNB4CHRNA3 | |
| SCHEMBL14845638 | 0.72 | CHRNB2 (0.45) | CHRNB2CHRNA4ELANECHRNB4CHRNA3 | |
| SCHEMBL4276668 | 0.71 | CHRNB2 (0.38) | CHRNB2CHRNA4ELANECHRNB4CHRNA3 | |
| SCHEMBL19297613 | 0.71 | LIPG (0.46) | ACACBPIK3CAMTORLIPCLIPG | |
| SCHEMBL14845639 | 0.71 | CHRNB2 (0.38) | CHRNB2CHRNA4ELANECHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |