Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116172 | 0.85 | ATM (0.46) | PARP1KDM4EL3MBTL1GAATDP1 | |
| SCHEMBL388521 | 0.83 | PARP1 (0.61) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL31001112 | 0.83 | PARP1 (0.61) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL2381176 | 0.83 | PARP1 (0.61) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL29764528 | 0.83 | PARP1 (0.61) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL29351761 | 0.82 | PARP1 (0.64) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL4370629 | 0.82 | PARP1 (0.64) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL1259 | 0.82 | PARP1 (0.64) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| Chloroform SCHEMBL11735729 | 0.81 | PARP1 (0.58) | PARP1ALDH1A1KDM4EUSP2ALOX15 | |
| SCHEMBL3821379 | 0.81 | L3MBTL1 (0.56) | PARP1ALDH1A1KDM4EUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373317-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065275-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2010-06-10 | — | — | WO | disclosed |