Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12442952 | 0.87 | EPHX1 (0.41) | POLBPARP14HTR4SMN1; SMN2L3MBTL1 | |
| SCHEMBL7332383 | 0.84 | HTR4 (0.43) | HTR4DRD2DRD4 | |
| SCHEMBL14104114 | 0.83 | HSD11B1 (0.40) | POLBPARP14KDM4EHTR4SMN1; SMN2 | |
| SCHEMBL12788543 | 0.82 | CACNA1I (0.43) | ALDH1A1MEN1LMNAKMT2APOLB | |
| SCHEMBL5157288 | 0.82 | CARM1 (0.51) | PARP14SIGMAR1 | |
| SCHEMBL2607204 | 0.82 | NCF1 (0.41) | ALDH1A1LMNAMAPTKMT2APOLB | |
| SCHEMBL13713538 | 0.80 | POLB (0.36) | LMNAPOLBPARP14HTR4USP14 | |
| SCHEMBL25713253 | 0.79 | KDM4E (0.40) | PKMALDH1A1LMNAPOLBPARP14 | |
| SCHEMBL18595476 | 0.78 | POLB (0.40) | ALDH1A1LMNAMAPTTHRBKMT2A | |
| SCHEMBL12156690 | 0.78 | PIK3CD (0.41) | CYP2D6ALDH1A1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022262782-A1 | GLUTARIMIDE-SUBSTITUTED ISOXAZOLE FUSED RING COMPOUND, AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2022-12-22 | — | — | WO | disclosed |