Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30028551 | 1.00 | DDB1 (0.49) | DDB1CRBNCHRM2CHRM4CHRM1 | |
| SCHEMBL31632878 | 0.85 | DDB1 (0.66) | DDB1CRBNNPC1HTTALDH1A1 | |
| SCHEMBL30029495 | 0.79 | DTYMK (0.43) | CHRM2CHRM4CHRM1CHRM3NPC1 | |
| SCHEMBL24754834 | 0.79 | DTYMK (0.43) | CHRM2CHRM4CHRM1CHRM3NPC1 | |
| SCHEMBL30029207 | 0.79 | DDB1 (0.81) | DDB1CRBNGPR119 | |
| SCHEMBL31633135 | 0.78 | DDB1 (0.51) | DDB1CRBNNPC1HTTLMNA | |
| SCHEMBL31632843 | 0.76 | GPR119 (0.51) | DDB1CRBNALDH1A1GPR119 | |
| SCHEMBL24754190 | 0.75 | CCNT1 (0.41) | DDB1CRBNCHRM2CHRM4CHRM1 | |
| SCHEMBL30029433 | 0.75 | CCNT1 (0.41) | DDB1CRBNCHRM2CHRM4CHRM1 | |
| SCHEMBL4844156 | 0.74 | GPR119 (0.55) | CHRM2CHRM4CHRM1CHRM3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266248-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-12-22 | — | — | WO | disclosed |