Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027681 | 0.80 | TDP1 (0.72) | TDP1KMT2AGAANPC1MITF | |
| SCHEMBL29703247 | 0.80 | TDP1 (0.72) | TDP1KMT2AGAANPC1MITF | |
| Hydrochloric Acid SCHEMBL30088832 | 0.79 | TDP1 (0.70) | TDP1KMT2AGAANPC1MITF | |
| SCHEMBL24754241 | 0.78 | LMNA (0.67) | TDP1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL29703239 | 0.78 | TDP1 (0.69) | TDP1NPC1MITFPKMRAB9A | |
| SCHEMBL7894526 | 0.78 | TDP1 (0.69) | TDP1NPC1MITFPKMRAB9A | |
| SCHEMBL30579886 | 0.77 | TDP1 (0.64) | TDP1NPC1MITFPKMRAB9A | |
| SCHEMBL28244751 | 0.74 | TDP1 (0.60) | TDP1KMT2APLA2G10GAANPC1 | |
| SCHEMBL24754239 | 0.73 | KMT2A (0.42) | KMT2AGAASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24754234 | 0.72 | CYP1A2 (0.40) | TDP1KMT2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |