Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120652 | 0.94 | POLB (0.58) | POLBMTNR1AMTNR1BMAPTL3MBTL1 | |
| SCHEMBL8316646 | 0.88 | POLB (0.63) | POLBMTNR1AMTNR1BMAPTL3MBTL1 | |
| SCHEMBL8587545 | 0.86 | POLB (0.70) | POLBMAPTL3MBTL1HTTKMT2A | |
| SCHEMBL14817250 | 0.84 | KMT2A (0.59) | POLBL3MBTL1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL27950280 | 0.78 | CES2 (0.46) | POLBMTNR1AMTNR1BMAPTL3MBTL1 | |
| SCHEMBL27947134 | 0.78 | LMNA (0.61) | POLBMAPTL3MBTL1HTTKMT2A | |
| SCHEMBL4544899 | 0.78 | LMNA (0.61) | POLBMAPTL3MBTL1HTTKMT2A | |
| SCHEMBL12536537 | 0.77 | KMT2A (0.68) | POLBL3MBTL1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL3760925 | 0.77 | KMT2A (0.68) | POLBL3MBTL1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL12786949 | 0.77 | ELANE (0.52) | POLBMAPTL3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010060836-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-03 | — | — | WO | disclosed |