Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DTYMK | P23919 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP1 | P63208 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30029738 | 1.00 | TLR9 (0.40) | TLR9ACHETLR7MEN1KMT2A | |
| SCHEMBL30794148 | 0.87 | JAK2 (0.44) | CCNT1CDK9PRMT5 | |
| SCHEMBL30794238 | 0.87 | JAK2 (0.44) | CCNT1CDK9PRMT5 | |
| SCHEMBL26636825 | 0.87 | TLR9 (0.44) | TLR9ACHETLR7MEN1KMT2A | |
| SCHEMBL24754190 | 0.86 | CCNT1 (0.41) | TLR9ACHETLR7MEN1KMT2A | |
| SCHEMBL30029433 | 0.86 | CCNT1 (0.41) | TLR9ACHETLR7MEN1KMT2A | |
| SCHEMBL30706118 | 0.86 | HTR6 (0.46) | PRMT5 | |
| SCHEMBL30705958 | 0.86 | HTR6 (0.46) | PRMT5 | |
| SCHEMBL30705933 | 0.84 | HTR6 (0.44) | PRMT5 | |
| SCHEMBL30705889 | 0.83 | PRMT5 (0.46) | MEN1KMT2APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266248-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-12-22 | — | — | WO | disclosed |