Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | LIPE | Q05469 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CCR4 | P51679 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30434705 | 0.88 | MAPK1 (0.58) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL29494845 | 0.80 | SMN1; SMN2 (1.00) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL240269 | 0.80 | SMN1; SMN2 (1.00) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL7055864 | 0.79 | SMN1; SMN2 (0.64) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL7172986 | 0.78 | SMN1; SMN2 (0.96) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL10644755 | 0.78 | LMNA (0.57) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL14006333 | 0.78 | CYP1A2 (0.49) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL11065229 | 0.77 | MAPK1 (0.57) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL12386871 | 0.77 | LMNA (0.83) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL10818128 | 0.75 | TSHR (0.54) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377530-A2 | Modulation of neurogenesis by PDE inhibition | Braincells, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |