Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242170 | 0.83 | KMO (0.56) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL24766030 | 0.82 | KMT2A (0.47) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL24766039 | 0.81 | MAPT (0.47) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL241043 | 0.78 | PIK3CB (0.57) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL244072 | 0.78 | PIK3CA (0.47) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL29434078 | 0.78 | PIK3CA (0.47) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL8925427 | 0.78 | GSK3B (0.52) | GSK3BPIK3CBPIK3CDPIK3CAKMO | |
| SCHEMBL17204101 | 0.77 | MAPT (0.61) | TSHRMAPTCYP1A2CYP2D6PIK3CB | |
| SCHEMBL24766006 | 0.77 | ALDH1A1 (0.48) | USP2TSHRTDP1MAPTCYP1A2 | |
| SCHEMBL24766029 | 0.74 | PTGS2 (0.47) | USP2TSHRTDP1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |