Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660641 | 0.93 | MAPT (0.51) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL10359370 | 0.84 | KDM4E (0.59) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL2376058 | 0.83 | MAPT (0.54) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL14380211 | 0.81 | MAPT (0.53) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL17565202 | 0.81 | KDM4E (0.42) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL2448020 | 0.79 | HSD17B10 (0.42) | MAPTHPGDMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL9349699 | 0.77 | MAPT (0.45) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL64932 | 0.76 | ALDH1A1 (0.58) | MAPTHPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL2799797 | 0.75 | MAPT (0.53) | MAPTHPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL17087123 | 0.75 | MAPT (0.53) | MAPTHPGDMAPK1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376473-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Canada Inc. (CA) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066028-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-06-17 | — | — | WO | disclosed |