SCHEMBL2476836

SCHEMBL2476836

CCOc1cccc(NC(=O)NC(CCCN(C)C)c2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)c1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 10/20 0.48
RECQL P46063 1/20 0.43
CACNA1H O95180 3/20 0.41
CACNA1B Q00975 2/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
TSHR P16473 1/20 0.40
LMNA P02545 1/20 0.40
PLAU P00749 1/20 0.39
IGF1R P08069 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475911 0.95 UTS2R (0.53) UTS2RRECQLKMT2AMEN1TSHR
SCHEMBL2475578 0.92 UTS2R (0.47) UTS2RCACNA1HCACNA1BKMT2AMEN1
SCHEMBL2478995 0.88 HDAC1 (0.51) UTS2RRECQLCACNA1HCACNA1BKMT2A
SCHEMBL2480439 0.85 UTS2R (0.47) UTS2R
SCHEMBL2474055 0.84 UTS2R (0.47) UTS2RSMN1; SMN2
SCHEMBL3227174 0.84 UTS2R (0.41) UTS2RKMT2AMEN1TSHR
SCHEMBL3832774 0.84 UTS2R (0.53) UTS2R
SCHEMBL2475610 0.84 NAMPT (0.52) UTS2RSMN1; SMN2
SCHEMBL2479563 0.83 UTS2R (0.44) UTS2R
SCHEMBL2478122 0.83 UTS2R (0.42) UTS2RKMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
EP-2107052-B1 NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE SANTEN PHARMACEUTICAL CO LTD (JP) 2011-10-12 EP disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed
EP-2107052-A1 NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE Santen Pharmaceutical Co., Ltd (JP) 2009-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 UTS2R 11/4885RECQL 1818/4885CACNA1H 1933/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.