Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 16/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30017365 | 1.00 | POLQ (0.42) | POLQMAPTNQO2GAA | |
| SCHEMBL24769266 | 0.94 | POLQ (0.47) | POLQ | |
| SCHEMBL25310764 | 0.87 | POLQ (0.47) | POLQMAPT | |
| SCHEMBL24770892 | 0.84 | POLQ (0.56) | POLQ | |
| SCHEMBL30017513 | 0.84 | POLQ (0.56) | POLQ | |
| SCHEMBL2217864 | 0.83 | GAA (0.42) | POLQMAPTNQO2GAA | |
| SCHEMBL29425147 | 0.83 | GAA (0.42) | POLQMAPTNQO2GAA | |
| SCHEMBL4750181 | 0.83 | GAA (0.42) | MAPTNQO2GAA | |
| SCHEMBL24770873 | 0.82 | POLQ (0.60) | POLQGAA | |
| SCHEMBL24770191 | 0.82 | POLQ (0.50) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122221-A1 | SIX-MEMBERED CYCLOTHIAZOLE COMPOUND AND USE THEREOF | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2025-04-17 | — | — | US | disclosed |
| EP-4464709-A1 | SIX-MEMBERED CYCLOTHIAZOLE COMPOUND AND USE THEREOF | Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) | 2024-11-20 | — | — | EP | disclosed |
| WO-2023202623-A1 | POLQ INHIBITOR COMPOUND AND USE THEREOF | 南京再明医药有限公司 | 2023-10-26 | — | — | WO | disclosed |
| WO-2023134739-A1 | SIX-MEMBERED CYCLOTHIAZOLE COMPOUND AND USE THEREOF | 南京再明医药有限公司 | 2023-07-20 | — | — | WO | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122221-A1 | SIX-MEMBERED CYCLOTHIAZOLE COMPOUND AND USE THEREOF | POLRMT, POLQ, POLH | POLQ 2/4885MAPT 99/4885NQO2 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.