Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9395767 | 0.85 | RAB9A (0.49) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL9391041 | 0.79 | CTSC (0.41) | DHODHEPHX2TRPV1HTTLMNA | |
| SCHEMBL10389192 | 0.78 | EPHX2 (0.51) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL2905610 | 0.78 | DHODH (0.55) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL29054967 | 0.77 | DHODH (0.50) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL10340303 | 0.76 | DHODH (0.49) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL10390169 | 0.76 | DHODH (0.49) | DHODHEPHX2TRPV1HTTALDH1A1 | |
| SCHEMBL11510708 | 0.75 | MLYCD (0.65) | EPHX2TRPV1HTTALDH1A1LMNA | |
| SCHEMBL9818928 | 0.74 | EPHX2 (0.50) | DHODHEPHX2TRPV1RAB9ARORC | |
| SCHEMBL10738492 | 0.73 | EPHX2 (0.66) | EPHX2TRPV1HTTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | RHIZEN PHARMACEUTICALS AG (CH) | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | DHODH, FLT3, IDH3A | DHODH 1/4885EPHX2 558/4885TRPV1 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.